Home Articles List Article Information
Egyptian Journal of Botany
Journal Archive
Volume Volume 64 (2024)
Volume Volume 63 (2023)
Volume Volume 62 (2022)
Volume Volume 61 (2021)
Volume Volume 60 (2020)
Volume Volume 59 (2019)
Volume Volume 58 (2018)
Volume Volume 57 (2017)
Volume Volume 56 (2016)
Volume Volume 55 (2015)
Volume Volume 54 (2014)
Hafez, R., Fouad, A. (2020). Mitigation of Genotoxic and Cytotoxic Effects of Silver Nanoparticles on Onion Root Tips using some Antioxidant Scavengers. Egyptian Journal of Botany, 60(1), 133-145. doi: 10.21608/ejbo.2019.13390.1321
Rehab Hafez; Ahmed Fouad. "Mitigation of Genotoxic and Cytotoxic Effects of Silver Nanoparticles on Onion Root Tips using some Antioxidant Scavengers". Egyptian Journal of Botany, 60, 1, 2020, 133-145. doi: 10.21608/ejbo.2019.13390.1321
Hafez, R., Fouad, A. (2020). 'Mitigation of Genotoxic and Cytotoxic Effects of Silver Nanoparticles on Onion Root Tips using some Antioxidant Scavengers', Egyptian Journal of Botany, 60(1), pp. 133-145. doi: 10.21608/ejbo.2019.13390.1321
Hafez, R., Fouad, A. Mitigation of Genotoxic and Cytotoxic Effects of Silver Nanoparticles on Onion Root Tips using some Antioxidant Scavengers. Egyptian Journal of Botany, 2020; 60(1): 133-145. doi: 10.21608/ejbo.2019.13390.1321

Mitigation of Genotoxic and Cytotoxic Effects of Silver Nanoparticles on Onion Root Tips using some Antioxidant Scavengers

Article 11, Volume 60, Issue 1, April 2020, Page 133-145  XML PDF (1.94 MB)
Document Type: Regular issue (Original Article)
DOI: 10.21608/ejbo.2019.13390.1321
Cited by Scopus (21)
View on SCiNiTO View on SCiNiTO
Authors
Rehab Hafez email orcid ; Ahmed Fouadorcid
Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt
Abstract
THE TARGET of this study is to use Allium cepa roots as model to evaluate the potential use of three antioxidants scavengers [vitamin C (VC), vitamin E (VE) and butylated hydroxytoluene (BHT)], either singly or in combination, in mitigation of genotoxic and cytotoxic effects of silver nanoparticles (AgNPs). The results indicated that AgNPs manifested mitodepressive and genotoxic symptoms, represented as decrease in mitotic index (MI), elevated total chromosome aberrations (TCA) and tail DNA (tDNA) associated with oxidative stress markers represented by increase in malonaldehyde (MDA) and hydrogen peroxide (H2O2) contents. Each of VC, VE and 1:1:1 mix of VC, VE and BHT ameliorated the harmful effects of AgNPs with best performance recorded for VE. Though, BHT decreased AgNPs-generated MDA and H2O2; it enforced the mitodepressive and genotoxic properties associated with application of nanoparticles. The results also reflected superiority of pretreatment over co-treatment with antioxidants in mitigation of the AgNPs-associated hazards.
Keywords
antioxidants; Chromosome aberrations; Comet assay; Mitotic index; Onion; silver nanoparticles
Statistics
Article View: 1,023
PDF Download: 955