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Egyptian Journal of Botany
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Volume Volume 61 (2021)
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Hassan, S., Hamed, S., Almuhayawi, M., Hozzein, W., Selim, S., AbdElgawad, H. (2021). Bioactivity of Ellagic Acid and Velutin: Two Phenolic Compounds Isolated from Marine Algae. Egyptian Journal of Botany, 61(1), 219-231. doi: 10.21608/ejbo.2020.23778.1456
Sherif Hassan; Seham Hamed; Mohammed Almuhayawi; Wael Hozzein; Samy Selim; Hammada AbdElgawad. "Bioactivity of Ellagic Acid and Velutin: Two Phenolic Compounds Isolated from Marine Algae". Egyptian Journal of Botany, 61, 1, 2021, 219-231. doi: 10.21608/ejbo.2020.23778.1456
Hassan, S., Hamed, S., Almuhayawi, M., Hozzein, W., Selim, S., AbdElgawad, H. (2021). 'Bioactivity of Ellagic Acid and Velutin: Two Phenolic Compounds Isolated from Marine Algae', Egyptian Journal of Botany, 61(1), pp. 219-231. doi: 10.21608/ejbo.2020.23778.1456
Hassan, S., Hamed, S., Almuhayawi, M., Hozzein, W., Selim, S., AbdElgawad, H. Bioactivity of Ellagic Acid and Velutin: Two Phenolic Compounds Isolated from Marine Algae. Egyptian Journal of Botany, 2021; 61(1): 219-231. doi: 10.21608/ejbo.2020.23778.1456

Bioactivity of Ellagic Acid and Velutin: Two Phenolic Compounds Isolated from Marine Algae

Article 16, Volume 61, Issue 1, Spring 2021, Page 219-231  XML PDF (1.26 MB)
Document Type: Original Article
DOI: 10.21608/ejbo.2020.23778.1456
Authors
Sherif Hassan email orcid 1; Seham Hamed2; Mohammed Almuhayawi3; Wael Hozzein1, 4; Samy Selim5, 6; Hammada AbdElgawad1
1Department of Botany and Microbiology, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt
2Soil Microbiology Department, Soils, Water and Environment Research Institute, Agricultural Research Center, P.O. 175, El-Orman, Giza, Egypt
3Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
4Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia
5Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, P.O. 2014, Saudi Arabia
6Botany Department, Faculty of Science, Suez Canal University, Ismailia, P.O. 41522, Egypt
Abstract
MARINE macroalgae are considered as a promising source of chemical compounds with a broad array of biological activities. The bioactive compounds of five marine seaweeds (Ulva lactuca, Padina boryana, Cystoseira myrica, Liagora farinosa and Acanthophora spicifera) were extracted by chloroform, dichloromethane and ethanol. We managed to extract two polyphenolic compounds (ellagic acid and velutin) from the dichloromethane extract of P. boryana and ethanol extract of A. spicifera, respectively. The biological activities of the two isolated compounds as well as the crude extracts were screened. All tested algal extracts showed high antimicrobial activity against target bacteria and fungi except for Pseudomonas aeruginosa was resistant to U. lactuca and C. myrica extracts. Chloroform and ethanol extracts of A. spicifera, and dichloromethane extract of C. myrica showed the highest antimicrobial activity against Bacillus subtilis and Staphylococcus aureus. Dichloromethane extract of P. boryana had the highest antiprotozoal activity against Trypanosoma cruzi and Leishmania donovani (IC50 values, 3.5 and 4.8 μg/mL, respectively), and potent antioxidant activity up to 60 %. Overall, marine macroalgae with high polyphenols and flavonoids content exhibited excellent antimicrobial, antiprotozoal and antioxidant properties. Purified velutin recorded high antimicrobial activities as compared to the tested antibiotics and both ellagic acid and velutin also possessed considerable antiprotozoal activities. This study suggests that, ellagic acid and velutin comprise the key players for the antimicrobial and antiprotozoal activities of P. boryana and A. spicifera extracts, respectively. Thus, these two compounds could be used as pharmaceutically bioactive natural compounds.
Keywords
Antimicrobial; Antioxidant; Antiprotozoal; Ellagic acid; Marine algae; Velutin
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